Testosterone Replacement Therapy

“Testosterone Replacement Therapy” these words have become more common with every passing year but many still have no clue as to what testosterone replacement therapy really is. You’ve seen the commercials for “Low-T” and if you ask most men they sound great but many still have no clue “Low-T” is nothing more than testosterone replacement therapy and this therapy unknown to even more is nothing more than a legal prescription for anabolic steroids. That’s right, anabolic steroids; testosterone replacement therapy refers to a treatment in-which low levels of the naturally occurring hormone testosterone are brought back into an adequate range. To perform this function the anabolic steroid testosterone, a synthetic version of the hormone our body produces must be administered.

If you possess any understanding of the performance enhancing world, on its surface the idea of testosterone replacement therapy may bring you a sigh of relief but more than likely it probably irritates you at the same time. After all, for years we’ve been told anabolic steroids are brewed in the bowels of hell but if you receive testosterone replacement therapy this same hormone from which all anabolic steroids are derived from, now it’s a welcomed beacon of hope. Yes, you are correct; episodes of the Twilight Zone make far more sense than this confusing conundrum.

Let’s from this point on be clear and precise; these advertisements for “Low-T” treatment and things of this nature are nothing more than advertisements and promotions for anabolic steroids. When you inquire about testosterone replacement therapy understand you’re inquiring regarding anabolic steroids; let’s call a spade a spade. We are still a long way off from anabolic steroids being generally accepted by the whole of society but it is within testosterone replacement therapy this acceptance holds its most promising form. ,/p>

If you are still unfamiliar with testosterone replacement therapy the idea is very simple. Testosterone replacement therapy is simply providing the body the testosterone it needs in-which it no longer produces naturally. Further, this same therapy is many times provided to increase testosterone levels in men who may not have a decline per say but who naturally do not make enough testosterone. This is where things find themselves a little murky; there isn’t a set level of testosterone production that is considered “Natural,” for the amounts produced vary from person to person. Even so, the idea is sound and very well received by most all men who receive it.

There are those who desire to see testosterone replacement therapy thrown into the trash pile of life; why? We don’t have a good specific answer for you because they have yet to give one themselves. Men who receive testosterone replacement therapy enjoy a higher quality of life, they feel better, and they become sick far less often and are generally happier individuals. Why on earth anyone would ever want to legislate testosterone replacement therapy into the ground is beyond reason and comprehension.

Athletes As Young As 12 Using Performance-Enhancing Drugs

A recent study in Australia has shown that young elite level athletes are turning to performance-enhancing drugs, some as young as 12-years old.

The three-year study by Griffith University and the University of Canberra, interviewed 938 athletes aged between 12-17, found that around 4% were using performance or image enhancing drugs (PEDs).

The study - Tracking the Development of Attitudes to Doping: A Longitudinal Study of Young Elite Athletes, set out with three specific aims:

    To assess the incidence of performance enhancing drug use among 12-17 year olds.
    To assess attitudes towards performance enhancing drug use among 12-17 year olds.
    To examine the relationships between individual characteristics, sporting history, social environment, and attitudes towards performance enhancing drug use.

Dr Stephen Moston – the associate professor at the University of Canberra – who co-authored the study with Griffith University’s Dr Terry Engelberg and Professor James Skinner, thinks the blame is put on not testing young athletes.

There is evidence suggesting that athletes as young as 12 years of age use performance enhancing drugs, and that such use has increased in the past decade. This study indicates that performance enhancing drugs and supplement use (a potential precursor of doping) are now relatively prevalent amongst young elite athletes. Given that young athletes are rarely subject to anti-doping testing, the potential increase of drug use is largely going unchecked. Both anti-doping education and detection efforts must be expanded to incorporate such populations.

Key findings of the report are:

    Younger athletes are more likely than their adult counterparts to think doping is common among the sports top stars, suspecting 1/3 take prohibited drugs.
    Almost 5% have been offered performance-enhancing drugs and 10% think their competition is are using drugs.
    About 1/3 use nutritional dietary supplements to enhance performance, including whey protein shakes and creatine.

The findings would shock the public and that young athletes were still cheating, regardless of their age and that athletes would seek to avoid testing.

One in five athletes aged over 18 believed their peers were using banned drugs to obtain an unfair advantage and males were more likely to use performance-enhancing drugs than females.

Athletics, cycling and rugby league were the most common sports were doping was evident and need to increase the frequency of testing.

In adult athletes, the report found 8% had been offered PEDs, whilst the adult sporting community think that 20% of their peers are using PEDs.

Young men dying from heart disease linked to steroid use

Men in their late 20s and early 30s who abuse steroids are dying from serious heart disease, a study has revealed.

But researchers say increasing numbers of steroid users are oblivious to the severe health risks linked to performance-enhancing drugs, including cardiovascular disease, reproductive failure, liver damage and high levels of aggression.

Nearly all men showed obvious signs of chronic steroid abuse, including overdeveloped muscles and shrunken, scarred testicles

The irony is that steroid users are often health-oriented, but they're using a drug that is damaging their bodies to the point it could kill.

The study examined 24 deaths in men aged 22 to 48 over the past 17 years where steroids were found in the system of the person who had died. Nearly all men - most employed as personal trainers, body builders and security guards - showed obvious signs of chronic steroid abuse, including overdeveloped muscles and shrunken, scarred testicles.

These men are doing major damage to their hearts and are substantially increasing their risk of death. For a very young group in their early 30s, their cardiac health looks like what you would expect of someone twice their age. More than half the men analysed had shrunken testicles, which is likely to impair the reproductive system.

While steroids were not the direct cause of death, 62.5 per cent of men died from taking toxic amounts of steroids together with other illicit drugs - including cocaine and methamphetamine - either alone or in combination with heart disease. More than half had serious heart disease, including thickened arteries and damaged heart muscles.

About a quarter of deaths were caused by suicide or homicide, which links long-term steroid use with an increased risk of aggressive and violent behaviour.

Steroid Use and Liver Cancer

Anabolic steroids have their legitimate uses, but abusing them can bring on a variety of health problems - some of which are connected to liver cancer.


Although well-documented reports linking steroids to liver cancer are rare, as more athletes use drugs to improve their performance or build their bodies, many types of dangerous side effects from the abuse of anabolic steroids are becoming known — and events are becoming more frequent.

Recently, there have been many instances in the news about famous athletes and performance-enhancing drugs, sometimes referred to as "doping." In most cases, the drugs that are being used are anabolic steroids. These drugs are manufactured steroids that behave like the male hormone testosterone. In the United States, it is illegal to use anabolic steroids without a prescription.

"Anabolic steroids are male-related hormones that can be used to increase muscle mass. When these drugs are abused they can have many side effects, including liver damage.

Liver Cancer: What Anabolic Steroids Can Treat

Anabolic steroids, under a doctor's prescription, will treat certain conditions in which increasing bone strength and muscle mass are required for health reasons. These medications can be helpful in the following types of cases:

    Delayed puberty
    Testosterone deficiency
    AIDS-related weakness

Liver Cancer: Anabolic Steroid-Related Liver Damage

Liver damage from anabolic steroids can cause a condition called cholestasis. With this condition, bile, a digestive fluid made in your liver, cannot get to where it needs to go and leaks out into your blood. Symptoms include:

    Itching
    Nausea
    Loss of appetite
    Dark urine
    Jaundice — the yellow discoloration of your eyes and skin

Damage to the liver is evident when enzymes called aminotransferases leak out of damaged liver cells into your bloodstream.

Another important point about anabolic steroids: They can be addictive. These steroids can cause steroid craving that leads to the need for more frequent and higher drug doses. Liver damage has been shown to be related to the cumulative effects of higher and more frequent use.

Liver Cancer: Can Anabolic Steroids Cause It?

Reports exist showing a slightly increased risk of developing liver cancer with long-term use of high-dose anabolic steroids. However,  the scientific evidence supporting a cause-and-effect relationship is weak.

But these steroids are known to cause tumors that form in your liver. Called hepatic adenomas, these tumors are not cancerous. However, they are dangerous because they can rupture and cause serious bleeding in the liver. There have been several reported deaths caused by bleeding from ruptured hepatic adenomas. The link between hepatic adenomas and anabolic steroid use in athletes is increasing. Recently, a case of a hepatic adenoma turning into liver cancer was reported.

Liver Cancer: Anabolic Side Effects

While there is not a strong link between liver cancer and anabolic steroids, there is strong evidence for serious liver damage. Other side effects of anabolic steroids include:

    High blood pressure
    Increased levels of bad cholesterol
    Mood swings
    Aggressive behavior
    Infertility in men
    Menstrual abnormalities in women

If you are an athlete or a body-builder and you are tempted to use anabolic steroids, consider that besides the legal and social risks involved, these drugs can and do cause life-theatening medical complications.

Higher Steroid Hormone Levels in Pregnancy Can Cause Autism in Children

Researchers exploring the causes of autism have linked higher levels of steroid hormones in the womb during early fetal development to autism spectrum disorder.

These hormones, which play a key phase in brain development at three to four months of pregnancy, may also explain why the condition is far more common among males than females, they said.

But it was too early to say whether higher hormone levels were a cause of autism, the team wrote, and cautioned against hormone screening or treatment based on their preliminary findings.

Scientists at the University of Cambridge in Britain and Denmark's Statens Serum Institute analyzed hormone levels among nearly 20,000 stored samples of amniotic fluid, which surrounds the fetus in the uterus.

The team measured levels of four "sex" steroid hormones -- testosterone, progesterone, 17-alpha-hydroxy-progesterone and androstenedione -- which are known to play a role in brain development.

They also looked at a fifth hormone, cortisol, which is a marker of stress.

The researchers found higher hormone levels in the amniotic fluid in 128 males who were later diagnosed with autism spectrum disorder.

All autistic subgroups were found to have the signature: Asperger syndrome, classic autism or a category called unspecified pervasive developmental disorder.

"This is one of the earliest non-genetic biomarkers that has been identified in children who go on to develop autism," said Simon Baron-Cohen, a University of Cambridge professor.

"We previously knew that elevated prenatal testosterone is associated with slower social and language development, better attention to detail and more autistic traits.

"Now, for the first time, we have also shown that these steroid hormones are elevated in children clinically diagnosed with autism. Because some of these hormones are produced in much higher quantities in males than in females, this may help us explain why autism is more common in males."

It was not known what causes the higher steroid levels in the first place, and the team cautioned against using the findings as a tool to screen for autism.

Nor should drugs be used to block steroid hormones.

"This could have unwanted side effects and may have little to no effect," said Baron-Cohen.

Only males were tested in the first phase of research. The next step will be to see if a similar telltale exists for females.

"Steroid hormones are particularly important because they exert influence on the process of how instructions in the genetic code are translated into building proteins," co-researcher Craig Brierley said in an email exchange with AFP.

The study appeared in the journal Molecular Psychiatry.

The cause of autism, a complex neurodevelopmental disorder characterized by social withdrawal, is considered to be roughly split between genetic and environmental factors, according to a study last month in the Journal of the American Medical Association (JAMA).

Steroids Ineffective and Possibly Harmful in Pediatric Liver Disease

Treating infants with high doses of steroids fails to improve medical outcomes in the end-stage pediatric liver disease biliary atresia and leads to earlier onset of serious adverse events, says a new study.

Researchers say the clinical trial involving 14 sites provides new evidence on a growing controversy in the medical community - whether treating infants with steroids to augment surgery improves outcomes.

The results from this clinical trial differ from previous reports of a benefit from steroid therapy on bile drainage or survival in biliary atresia. Although it cannot be excluded some small potential benefit from steroid treatment, observed no statistical differences in two-year survival between patients receiving steroid treatment after surgery and those receiving placebo. Children receiving steroids during the study also developed serious adverse events more quickly, raising a potential increase in risks associated with steroid therapy.

Biliary atresia is the leading cause of pediatric liver transplantation in the world. The disease accounts for about 50 percent of transplants in children and 10 percent of transplants at any age. It results from inflammation and rapid accumulation of connective tissues that obstruct and restrict bile ducts from draining. The condition then manifests as cholestatic jaundice in the first few weeks after birth.

At diagnosis, the primary treatment is the hepatoportoenterostomy (HPE, the Kasai procedure) - a surgical procedure that removes the diseased bile ducts and gallbladder and connects an intestinal loop directly to the liver to restore bile drainage. Study authors point out that some clinicians suggest steroid treatment after surgery may help prevent additional fibrosis and improve bile drainage. The current study - called START (Steroids in Biliary Atresia Randomized Trial) - was designed to provide rigorous medical data to help answer that question.

The study involved 140 infants with a median age of 2.3 months. The initial study was conducted between September 2005 and February 2011, with follow up ending in January 2013.

Researchers report that in 70 children treated with steroids, bile drainage was not significantly different six months post-surgery compared to 70 children who received placebo after surgery. Of the 70 who received steroids, 41 of 70 patients (58.6 percent) had improved bile drainage. Of 70 patients who did not receive steroids, 34 of 70 (48.6 percent) had improved bile drainage.

When researchers compared survival rates between the steroid/non-steroid groups at age 24 months, 58.7 percent of children in the steroid group survived compared to 59.4 percent in the placebo group.

The percent of children who experienced serious safety events was relatively the same between the steroid group (81.4 percent) and non-steroid group (80 percent), but children who received steroids had an earlier time to onset for those events. Serious safety events occurred with 30 days post-surgery in 37.2 percent of children who received steroid treatment, versus 19 percent in the placebo group.

Potential serious safety events the authors pointed to included complications such as immunosuppression, associated risk of infection, poor wound healing, hyperglycemia, gastrointestinal bleeding, poor growth, and inadequate response to routine immunizations.

The Use of Human Growth Hormone in the treatment of HIV / AIDS

HIV (human immunodeficiency virus) is the virus that causes AIDS (acquired immune deficiency syndrome). The HIV retrovirus may be passed from one person to another when infected blood, semen, vaginal secretions or other bodily fluids come in contact with an uninfected person's broken skin or mucous membranes. People with HIV have what is called HIV infection and are fit and well. Some of these people will develop AIDS as a result of their HIV infection.

Growth hormone is a popular bodybuilding and performance enhancing aid, and the use of recombinant human growth hormone (rHGH, or simply GH) to treat various conditions in HIV infection has been debated with excitement for years. Indeed it is licensed for the treatment of wasting syndrome in advanced stages of AIDS. GH is also a commonly used bodybuilding and performance enhancing drug, which can be purchased on the black market; used to help both muscle anabolism / strength and reduction in body fat levels. Both of these applications have possible significance in the treatment of HIV.

Other than in the treatment of wasting disease, results from the studies using rHGH to treat body changes associated with HIV and/or drugs used to treat HIV have been very favourable. One which has been studied extensively is the use of rHGH in reducing HIV-associated adipose redistribution syndrome (HARS). However, the positive effects of HGH treatment in HIV may be more direct. Several studies have proposed that rHGH may bolster the immune system in ways that might improve clinical outcomes in HIV.

Let's look at each of the possible treatment benefits of rHGH in HIV in turn:

HIV-associated adipose redistribution syndrome (HARS)
HARS is a type of lipodystrophy (abnormal distribution of body fat), where there is accumulation of excess truncal fat and visceral adipose tissue, as opposed to regular gynoid (glutes and hips) or android (abdomen) deposition. This is observed in HIV infected people, moreso as virus load increases. Although not a debilitating condition in itself (indeed extra body fat can prolong life if followed by wasting), HARS is unpleasant for the individual, giving reduced confidence in body image; another negative aspect of the disease.

rHGH therapy has been shown to significantly reduce HARS, leading to an improved body image, and significant improvement in psychological well-being. Numerous studies have demonstrated the benefits of this, leading to rHGH being licesenced for the treatment of HARS in some countries. It should also be noted that improvement in psychological well-being could also contribute to a positive clinical outcome, in that it reduces the effects of wasting.

Acute Infections
HIV patients are often more prone to acute infections which may take longer to clear up than in non-HIV individuals. Sometimes these can be associated with poor appetite and weight loss. rHGH therapy may curb rapid weight loss often associated with acute infections in HIV positive people and may also reduce length of infection. Far more research is needed here though.

Fasting lipid profile
HIV patients have been shown to have elevated serum lipids, and dyslipidaemia, i.e. high LDL (bad) cholesterol and low HDL (good) cholesterol with raised total cholesterol and triglycerides. This is associated with anti-HIV drug treatment especially later on in infection. This does increase risk of cardiovascular diseases, and rHGH treatment may improve lipid profiles.

Bone Building
HIV patients may have loss of bone density associated with wasting. Both treatment with rHGH and growth hormone releasing factor (GHRF) have indicated improved bone mass in HIV patients (Koutkia et al 2005).

Side effects of rHGH treatment
Although we have focused on the promising benefits for rHGH treatment in HIV infection, consideration of possible side effects is important in ensuring an informed decision can be made. Side effects of rHGH therapy include possible joint pain (arthralgia), abnormal growth of the body's extremities and impaired glucose intolerance, increasing the risk of type 2 diabetes.

Caution is also advised against using over-the-counter or faddy internet products that claim to contain human growth hormone. Some of them claim to contain plant-derived growth hormone, others claim to contain cow or goat growth hormone, and still others claim to contain substances that increase the body's production of GH. There is no evidence that any of these products contain either a relevant product or a dose needed to induce the types of effects seen in studies. Over-the-counter and internet sales of these 'growth hormone' products are a major source of health fraud.

Certainly rHGH has shown benefits in treating wasting syndrome in advanced stages of HIV disease or AIDS, and its approval as a treatment for body lipodystrophy is encouraging. However, it's important that larger studies confirm these early findings. They can tell us whether or not increases in thymus size and CD4+ cell numbers, associated with rHGH use, ultimately benefit people living with HIV and result in better quality of life and longer life. Treatment with GH in HIV is encouraging and exciting, but far more research is still required.